USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: RENT1_HUMAN USC-OGP 2-DE database:  RENT1_HUMAN RENT1_HUMAN General information about the entry View entry in simple text format Entry name RENT1_HUMAN Primary accession number Q92900 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Regulator of nonsense transcripts 1; EC=3.6.4.-; AltName: Full=ATP-dependent helicase RENT1; AltName: Full=Nonsense mRNA reducing factor 1; Short=NORF1; AltName: Full=Up-frameshift suppressor 1 homolog; Short=hUpf1;. Gene name Name=UPF1 Synonyms=KIAA0221, RENT1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1100: pI=6.10; Mw=138108 Cross-references UniProtKB/Swiss-Prot Q92900; RENT1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name RENT1_HUMAN Primary accession number Q92900 Secondary accession number(s) O00239 O43343 Q86Z25 Q92842 Sequence was last modified on  October 18, 2001 (version 2) Annotations were last modified on  March 15, 2017 (version 176) Name and origin of the protein Description RecName: Full=Regulator of nonsense transcripts 1; EC=3.6.4.-; AltName: Full=ATP-dependent helicase RENT1; AltName: Full=Nonsense mRNA reducing factor 1; Short=NORF1; AltName: Full=Up-frameshift suppressor 1 homolog; Short=hUpf1; Gene name Name=UPF1 Synonyms=KIAA0221, RENT1 Encoded on Name=UPF1; Synonyms=KIAA0221, RENT1 Keywords 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase; Metal-binding; Methylation; Nonsense-mediated mRNA decay; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U65533; AAC50771.1; -; mRNA EMBL U59323; AAC51140.1; -; mRNA EMBL D86988; BAA19664.2; ALT_INIT; mRNA EMBL AF074016; AAC26788.1; -; mRNA EMBL AC003972; AAB94785.1; -; Genomic_DNA EMBL BC039817; AAH39817.1; -; mRNA CCDS CCDS12386.1; -. [Q92900-2]; . CCDS CCDS74315.1; -. [Q92900-1]; . RefSeq NP_001284478.1; NM_001297549.1. [Q92900-1]; . RefSeq NP_002902.2; NM_002911.3. [Q92900-2]; . UniGene Hs.515266; -; . PDB 2GJK; X-ray; 2.60 A; A=295-925 PDB 2GK6; X-ray; 2.40 A; A/B=295-925 PDB 2GK7; X-ray; 2.80 A; A=295-925 PDB 2IYK; X-ray; 2.95 A; A/B=115-272 PDB 2WJV; X-ray; 2.85 A; A/B=115-925 PDB 2WJY; X-ray; 2.50 A; A=115-925 PDB 2XZO; X-ray; 2.40 A; A=295-925 PDB 2XZP; X-ray; 2.72 A; A=295-925 PDBsum 2GJK; -; . PDBsum 2GK6; -; . PDBsum 2GK7; -; . PDBsum 2IYK; -; . PDBsum 2WJV; -; . PDBsum 2WJY; -; . PDBsum 2XZO; -; . PDBsum 2XZP; -; . ProteinModelPortal Q92900; -; . SMR Q92900; -; . BioGrid 111908; 159; . DIP DIP-29875N; -; . IntAct Q92900; 113; . MINT MINT-5005507; -; . STRING 9606.ENSP00000262803; -; . iPTMnet Q92900; -; . PhosphoSitePlus Q92900; -; . SwissPalm Q92900; -; . BioMuta UPF1; -; . DMDM 17380291; -; . EPD Q92900; -; . MaxQB Q92900; -; . PaxDb Q92900; -; . PeptideAtlas Q92900; -; . PRIDE Q92900; -; . Ensembl ENST00000262803; ENSP00000262803; ENSG00000005007. [Q92900-2]; . Ensembl ENST00000599848; ENSP00000470142; ENSG00000005007. [Q92900-1]; . GeneID 5976; -; . KEGG hsa:5976; -; . UCSC uc002nkf.4; human. [Q92900-1]; . CTD 5976; -; . DisGeNET 5976; -; . GeneCards UPF1; -; . HGNC HGNC:9962; UPF1; . HPA HPA019587; -; . HPA HPA020857; -; . MIM 601430; gene; . neXtProt NX_Q92900; -; . OpenTargets ENSG00000005007; -; . PharmGKB PA34328; -; . eggNOG KOG1802; Eukaryota; . eggNOG COG1112; LUCA; . GeneTree ENSGT00800000124068; -; . HOGENOM HOG000205990; -; . HOVERGEN HBG061556; -; . InParanoid Q92900; -; . KO K14326; -; . OMA HDSIGYI; -; . OrthoDB EOG091G01B6; -; . PhylomeDB Q92900; -; . TreeFam TF300554; -; . Reactome R-HSA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); . Reactome R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); . SIGNOR Q92900; -; . ChiTaRS UPF1; human; . EvolutionaryTrace Q92900; -; . GeneWiki UPF1; -; . GenomeRNAi 5976; -; . PRO PR:Q92900; -; . Proteomes UP000005640; Chromosome 19; . Bgee ENSG00000005007; -; . CleanEx HS_UPF1; -; . ExpressionAtlas Q92900; baseline; . Genevisible Q92900; HS; . GO GO:0000785; C:chromatin; IDA:HGNC; . GO GO:0005737; C:cytoplasm; NAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0035145; C:exon-exon junction complex; IDA:UniProtKB; . GO GO:0000784; C:nuclear chromosome; telomeric region; IDA:BHF-UCL GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0000932; C:P-body; IEA:UniProtKB-SubCell; . GO GO:0044530; C:supraspliceosomal complex; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0004004; F:ATP-dependent RNA helicase activity; IDA:UniProtKB; . GO GO:0003682; F:chromatin binding; IDA:HGNC; . GO GO:0004386; F:helicase activity; NAS:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0042162; F:telomeric DNA binding; IDA:BHF-UCL; . GO GO:0008270; F:zinc ion binding; IEA:InterPro; . GO GO:0061158; P:3'-UTR-mediated mRNA destabilization; IMP:UniProtKB; . GO GO:0071347; P:cellular response to interleukin-1; IDA:UniProtKB; . GO GO:0071222; P:cellular response to lipopolysaccharide; IDA:UniProtKB; . GO GO:0006281; P:DNA repair; IDA:HGNC; . GO GO:0006260; P:DNA replication; IMP:HGNC; . GO GO:0009048; P:dosage compensation by inactivation of X chromosome; IEA:Ensembl; . GO GO:0071044; P:histone mRNA catabolic process; IMP:UniProtKB; . GO GO:0006406; P:mRNA export from nucleus; TAS:HGNC; . GO GO:0000956; P:nuclear-transcribed mRNA catabolic process; IMP:UniProtKB; . GO GO:0000294; P:nuclear-transcribed mRNA catabolic process; endonucleolytic cleavage-dependent decay; IMP:UniProtKB GO GO:0000184; P:nuclear-transcribed mRNA catabolic process; nonsense-mediated decay; IDA:UniProtKB GO GO:0061014; P:positive regulation of mRNA catabolic process; IMP:UniProtKB; . GO GO:0006449; P:regulation of translational termination; IMP:UniProtKB; . GO GO:0000723; P:telomere maintenance; IMP:BHF-UCL; . GO GO:0032201; P:telomere maintenance via semi-conservative replication; IDA:BHF-UCL; . Gene3D 3.40.50.300; -; 3; . InterPro IPR006935; Helicase/UvrB_N; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR018999; RNA-helicase_UPF1_UPF2-interct; . Pfam PF04851; ResIII; 1; . Pfam PF09416; UPF1_Zn_bind; 1; . SUPFAM SSF52540; SSF52540; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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